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YKL 06-061
CAS No. 2172617-15-9
YKL 06-061( YKL06-061 )
Catalog No. M13473 CAS No. 2172617-15-9
YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 63 | In Stock |
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| 10MG | 113 | In Stock |
|
| 25MG | 210 | In Stock |
|
| 50MG | 357 | In Stock |
|
| 100MG | 552 | In Stock |
|
| 500MG | 1188 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameYKL 06-061
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NoteResearch use only, not for human use.
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Brief DescriptionYKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.
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DescriptionYKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively; inhibits only one kinase FRK (IC50=1.1 nM), more strongly than SIKs, in a panel of 468 human kinases; dose-dependently increases MITF mRNA expression in human melanoma cells; induces significant pigmentation in Mc1r-deficient mice and normal human skin.
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In VitroYKL 06-061 yields a dose-dependent increase in MITF mRNA expression. :RT-PC RCell Line:UACC62 human melanoma cells, and UACC257 human melanoma cells.Concentration:0-4 μM (UACC62); 0-16 μM (UACC257).Incubation Time:3 hours.Result:Yielded a dose-dependent increase in MITF mRNA expression.
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In Vivo——
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SynonymsYKL06-061
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PathwayAutophagy
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TargetSIK
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RecptorSIK
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Research Area——
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Indication——
Chemical Information
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CAS Number2172617-15-9
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Formula Weight527.673
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Molecular FormulaC30H37N7O2
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Purity>98% (HPLC)
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SolubilityDMSO : 62.5 mg/mL 118.45 mM; H2O : < 0.1 mg/mL
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SMILESO=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C
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Chemical NamePyrimido[4,5-d]pyrimidin-2(1H)-one,1-cyclobutyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mujahid N, et al. Cell Rep. 2017 Jun 13;19(11):2177-2184.
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