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YKL 06-061

CAS No. 2172617-15-9

YKL 06-061( YKL06-061 )

Catalog No. M13473 CAS No. 2172617-15-9

YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    YKL 06-061
  • Note
    Research use only, not for human use.
  • Brief Description
    YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.
  • Description
    YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively; inhibits only one kinase FRK (IC50=1.1 nM), more strongly than SIKs, in a panel of 468 human kinases; dose-dependently increases MITF mRNA expression in human melanoma cells; induces significant pigmentation in Mc1r-deficient mice and normal human skin.
  • In Vitro
    YKL 06-061 yields a dose-dependent increase in MITF mRNA expression. :RT-PC RCell Line:UACC62 human melanoma cells, and UACC257 human melanoma cells.Concentration:0-4 μM (UACC62); 0-16 μM (UACC257).Incubation Time:3 hours.Result:Yielded a dose-dependent increase in MITF mRNA expression.
  • In Vivo
    ——
  • Synonyms
    YKL06-061
  • Pathway
    Autophagy
  • Target
    SIK
  • Recptor
    SIK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2172617-15-9
  • Formula Weight
    527.673
  • Molecular Formula
    C30H37N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 62.5 mg/mL 118.45 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C
  • Chemical Name
    Pyrimido[4,5-d]pyrimidin-2(1H)-one,1-cyclobutyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mujahid N, et al. Cell Rep. 2017 Jun 13;19(11):2177-2184.
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